Endometrial cancer: hormonal factors, the perimenopausal "window of risk," and isoflavones.
نویسندگان
چکیده
Center for Women’s Health (G.E.H.), Cedars-Sinai Medical Center, Los Angeles, California 90048; Department of Medical and Scientific Services, Quintiles Inc. (C.L.H.), Research Triangle Park, North Carolina 27709-3979; Department of Obstetrics and Gynecology (C.L.H.), Duke University Medical Center, Durham, North Carolina 27710; and Department of Pathology (J.M.C.), Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157
منابع مشابه
فراوانی هیپرپلازی آندومتر و عوامل خطرساز آن در بیماران سنین 40-60 سالگی مراجعه کننده به بیمارستان شهید یحیی نژاد بابل در فاصله سالهای 82-1379
Background and Aim: Endometrial hyperplasia is the overgrowth of endometrial glands due to prolonged unopposed estrogenic stimulation. Its major clinical symptom is abnormal uterine bleeding (especially perimenopausal). The disease has several risk factors. The aim of this study was to assess the prevalence of endometrial hyperplasia and its risk factors in perimenopausal period in women who re...
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PTEN tumor suppressor inactivation is the earliest step in endometrial carcinogenesis, occurring in morphologically unremarkable endometrial glands in half of normal women. We test the hypothesis that sex hormones positively or negatively select for these "latent precancers" by examining their emergence, persistence, and regression rates under differing hormonal conditions. Perimenopausal and p...
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The number of women who need medical attention for perimenopausal bleeding has been increased because of the factors such as hormonal therapy after menopause. Determining the cause is essential in planning appropriate therapy. Although endometrial biopsy is still the preferred method as the first diagnostic test, hysterosonogeraphy (HSG) is a sensetive diagnostic method. 37 perimenopausal wom...
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Women with polycystic ovary syndrome (PCOS) have been reported to be at increased risk of a number of gynecological neoplasias, including endometrial, breast, and ovarian cancer. The data supporting an increased risk is almost entirely inferential, based primarily on small case series or shared risk factors. One of the difficulties in exploring the association between these cancers and PCOS, is...
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ورودعنوان ژورنال:
- The Journal of clinical endocrinology and metabolism
دوره 87 1 شماره
صفحات -
تاریخ انتشار 2002